GMI - Gregor Mendel Institute of Plant Molecular Biology, Dr. Bohr-Gasse 3, 1030 Vienna, Austria
Phone: +43 1 79044-9850 E-mail: yasin.dagdas(at)gmi.oeaw.ac.at
Role of autophagy in plant development and stress tolerance
Our lab studies how autophagy contributes to phenotypic plasticity responses that underlie environmental adaptation. We are combining biochemical and cell biological approaches to explore tissue and cell-type specific adaptive responses that employ autophagy. We are using Arabidopsis thaliana and Marchantia polymorpha as model organisms.
* Kellner R, De la Concepcion JC, Maqbool A, Kamoun S, Dagdas YF. (2016) ATG8 Expansion: A Driver of Selective Autophagy Diversification? Trends Plant Science.
* Maqbool A, Hughes RK, Dagdas YF, Tregidgo N, Zess E, Belhaj K, Round A, Bozkurt TO, Kamoun S, Banfield MJ. (2016) Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54. Journal of Biological Chemistry, 291(38):20270-82
* Yasin F. Dagdas, Khaoula Belhaj, Abbas Maqbool, Angela Chaparro-Garcia, Pooja Pandey, Benjamin Petre, Nadra Tabassum, Richard K. Hughes, Jan Sklenar, Joe Win, Frank Menke, Kim Findlay, Mark J. Banfield, Sophien Kamoun, and Tolga O. Bozkurt. (2016) An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor. eLIFE. 5. pii: e10856.
Projects within VBC Ubiquitin Club
ATG8 is a ubiquitin-like protein that plays important roles in selective cargo recruitment, autophagosome biogenesis and autophagic flux. Recently, we performed an extensive phylogenetic analysis that revealed diversification and expansion of ATG8 gene family in plants. The degree to which ATG8 expansion contributes to the diversification of autophagy responses is unclear. Our recent data suggest ATG8 isoforms are functionally specialized. Currently, we are using ATG8 specialization as a platform to explore autophagy signaling network in plants.